84P2A9: a prostate and testis specific protein highly expressed in prostate cancer
AssigneeAgensys, Inc.
InventorsAya Jakobovits, Daniel E. H. Afar, Pia M. Challita-Eid, Elana Levin, Steve Chappell Mitchell, Rene S. Hubert
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Abstract
A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphocytic and lung cancers. Consequently, 84P2A9 provides a diagnostic and/or therapeutic target for cancers, and the 84P2A9 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
Claims14
An isolated antibody or fragment thereof that immunospecifically binds to an epitope on a 84P2A9 protein comprising an amino acid sequence shown in SEQ ID NO:2.
Dependencies are inferred from the claim text.