Polyester based degradable materials and implantable biomedical articles formed therefrom
AssigneeThe University of North Carolina at Chapel Hill
InventorsValerie Ashby, David Olson
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Abstract
A method of making an aliphatic polyester prepolymer, comprising: reacting, alone or in combination with other reactants, a diol with at least a first diacid (or a diester of the first diacid) to produce an aliphatic polyester prepolymer. The first diacid is preferably a trans-beta-hydromuconic acid (HMA). In some embodiments, the diol contains at least one ether linkage. In some embodiments the diol is further reacted with at a second diacid, or a diester of the second diacid, wherein the second diacid is different from the first diacid. Prepolymers produced from such processes and articles formed therefrom are also described.
Claims13
A method of making an article comprising a thermoset elastomeric polymer, said method comprising:
- forming an aliphatic polyester prepolymer into said article, and then
- thermally crosslinking said prepolymer to produce said article;
- wherein said aliphatic polyester prepolymer is produced by the process comprising reacting a diol or polyol with at least a first diacid, or a diester of said first diacid, to produce said aliphatic polyester prepolymer;
- wherein said first diacid is a trans-beta-hydromuconic acid (HMA);
- said prepolymer further comprising a crosslinking agent;
- wherein said thermoset elastomeric polymer completely degrades within six months when immersed in phosphate buffered saline solution at 37° C.;
- and wherein said article has a Young's modulus of 0.02 MPa to 20 MPa.
A method of making an article comprising a thermoset elastomeric polymer, said method comprising:
- forming an aliphatic polyester prepolymer into said article, and then
- thermally crosslinking said prepolymer to produce said article;
- wherein:
- said aliphatic polyester prepolymer is produced by the process comprising reacting a diol with at least a first diacid, or a diester of said first diacid, to produce said aliphatic polyester prepolymer;
- wherein said first diacid is a trans-beta-hydromuconic acid (HMA), said prepolymer further comprising a crosslinking agent;
- said diol is a polyol selected from the group consisting of poly(ethylene glycol) and poly(propylene glycol);
- said prepolymer is liquid and amorphous at a temperature of 25° C.;
- said thermoset elastomeric polymer completely degrades within six months when immersed in phosphate buffered saline solution at 37° C.;
- and
- said article has a Young's modulus of 0.02 MPa to 20 MPa.
Dependencies are inferred from the claim text.