1-adamantyl chalcones for the treatment of proliferative disorders

A compound of the formula:

• wherein:
• R1 is Ad-(L1)n-, wherein n is 0 or 1, Ad is adamantyl, and L1 is C1-6 cycloalkylene or C1-6 arylene;
• R2 is phenyl or phenyl substituted by X;
• wherein X is straight chain or branched C1-6 alkyl, halo, amino, C1-6 alkyl amino, C1-6 dialkyl amino, pyrrolidinyl, piperadinyl, morpholinyl, piperazinyl, C1-6 alkoxy, C1-6 aralkoxyl, aryl, C1-6 aralkyl, nitro, cyano or a phosphorus containing group;
• and
• Y is H, C1-6 alkyl, aryl, or halo;
• or a pharmaceutically acceptable salt or derivative thereof.