US 8,013,018 B2 · Aminoindane derivative or salt thereof

Abstract

Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, or pain. A novel compound or a salt thereof, which is characterized in that it has an amino group and R1 (lower alkyl, cycloalkyl, -lower alkylene-aryl, aryl which may be substituted, and the like) on carbon atoms of indane, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine, or cyclopenta[c]pyridine ring, or 2,3 -dihydro-1-benzofuran, 2,3-dihydro-1-benzothiophene, indoline ring, or the like, and has R2 and R3 (the same or different, each lower alkyl or aryl) on carbon atoms beside them, and an NMDA receptor antagonist comprising the same as an active component.

Claims14

Dependent claims

A compound represented by the following formula (Ia) or a pharmaceutically acceptable salt thereof:

wherein R1 is lower alkyl, cycloalkyl, lower alkylene-aryl, aryl which may be substituted, heteroaryl which may be substituted, or lower alkyl substituted with one or more halogens;
R2 and R3 independently represent lower alkyl, or aryl;
R4 and R5 independently represent a hydrogen atom, lower alkyl, —O-lower alkyl, —OH, lower alkylene-OH, or lower alkylene-O-lower alkyl;
R6 to R9 independently represent a hydrogen atom, lower alkyl, —O-lower alkyl, a halogen atom, lower alkyl substituted with one or more halogens, OH, CN, lower alkenyl, or a nitrogen-containing heterocyclic group;
and
R10 and R11 independently represent a hydrogen atom, or lower alkyl,
provided that R2 and R3 may be taken together with the adjacent carbon atom to form cycloalkyl.

4 more elements

Dependencies are inferred from the claim text.

Aminoindane derivative or salt thereof

Life of this patent

Aminoindane derivative or salt thereof

Life of this patent

Abstract

Claims14