Small molecule inhibitors of ghrelin O-acyltransferase

A pharmaceutical composition comprising a ghrelin O-acyltransferase (GOAT) inhibitor of the structure 1:

• wherein:
• R1, is selected from unsubstituted n-heptanyl, unsubstituted n-heptenyl, unsubstituted n-heptynyl and unsubstituted methyl-diethylene glycol (—CH2OCH2CH2OCH2CH3);
• R2-R5 are independently selected from hydrogen, optionally hetero-, optionally substituted alkyl, optionally hetero-, optionally substituted alkenyl, optionally hetero-, optionally substituted alkynyl, optionally hetero-, optionally substituted aryl, and an optionally substituted heteroatom;
• A is selected from NH, and N-alkyl;
• G is O;
• X is selected from hydroxyl, amino, alkylamino, and alkylthio;
• Y is C;
• and
• Z is selected from O, S, NH and N-alkyl,
• or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient, wherein said inhibitor inhibits said ghrelin O-acyltransferase (GOAT), and said composition is suitable for pharmaceutical use.