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US 8,013,011 B2Granted
Treatment and prevention of benign pigmented moles (naevi) using artemisinine and the derivatives thereof
AssigneeEPIPHARM GmbH
InventorRosemarie Sift Carter
Life of this patent
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Abstract
A method of treating a benign pigmented mole or a dermatomycosis. The method comprises locally applying to a subject in need thereof artemisinine and/or one or more structurally related compounds. Also disclosed is a plaster which comprises a topical formulation comprising artemisinine and/or one or more structurally related compounds.
Claims13
A method of treating at least one benign pigmented mole, wherein the method comprises locally applying to a subject in need thereof one or more compounds of formula (I):
- wherein:
- X represents CO, CHOZ or CHNRZ;
- Z is selected from hydrogen;
- straight-chain and branched (C1-C6) alkyl;
- straight-chain or branched (C2-C6) alkenyl;
- straight-chain or branched (C2-C6) alkynyl;
- (C3-C8) cycloalkyl;
- (C6-C24) aryl;
- (C7-C24) aralkyl;
- m- and p-CH2(C6H4)COOM;
- COR3;
- CSR3;
- C(NR6)R3;
- SOR4;
- SO2OM;
- SO2NR7R8;
- SO2O-artemisinyl;
- SO2NH-artemisinyl;
- POR4R5;
- and PSR4R5;
- R3 is selected from straight-chain or branched (C1-C6) alkyl;
- straight-chain or branched (C1-C6) alkoxy;
- straight-chain or branched (C2-C6) alkenyl;
- straight-chain or branched (C2-C6) alkynyl;
- (C3-C8) cycloalkyl;
- (C6-C24) aryl;
- (C6-C10) aryloxy;
- (C7-C24) aralkyl;
- —(CH2)n—COOM, with n being an integer of from 1 to 6;
- and 10α-di-hydroartemisinyl;
- R4 and R5 are independently selected from straight-chain or branched (C1-C6) alkyl;
- straight-chain or branched (C2-C6) alkenyl;
- straight-chain or branched (C2-C6) alkynyl;
- (C3-C8) cycloalkyl;
- (C6-C24) aryl;
- (C7-C24) aralkyl;
- OM;
- straight-chain or branched (C1-C6) alkoxy;
- (C6-C10) aryloxy;
- and NR7R8;
- R6 is selected from straight-chain or branched (C1-C6) alkyl;
- straight-chain or branched (C2-C6) alkenyl;
- straight-chain or branched (C2-C6) alkynyl;
- (C3-C8) cycloalkyl;
- (C6-C24) aryl;
- and (C7-C24) aralkyl;
- M represents hydrogen or a pharmaceutically acceptable cation;
- R7 and R8 are independently selected from straight-chain or branched (C1-C6) alkyl, or R7 and R8 together form a (C4-C6) alkylene bridge;
- and
- R is selected from hydrogen;
- straight-chain or branched (C1-C6) alkyl;
- straight-chain or branched (C2-C6) alkenyl;
- straight-chain or branched (C2-C6) alkynyl;
- (C3-C8) cycloalkyl;
- (C6-C24) aryl;
- and (C7-C24) aralkyl.
53 more elements
Dependencies are inferred from the claim text.