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US 8,013,010 B2Granted
5-thioxylopyranose compounds
AssigneeLaboratoires Fournier S.A.
InventorsVéronique Barberousse, Didier Thomas, Michel Bondoux
Life of this patent
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Abstract
Compounds of 5-thioxylopyranose, preferably derivatives of the 5-thioxilopyranose type, a method for preparing such compounds, and the use of such compounds as an active ingredient in pharmaceutical compositions which are useful, in particular, for treating or inhibiting thrombosis or heart failure or thromboembolic disease states.
Claims12
A thioxylose compound selected from the group consisting of:
- a) compounds of formula I:
- wherein:
- the pentapyranosyl group represents a 5-thio-β-D-xylopyranosyl group,
- R represents a hydrogen atom or a C2-C6 acyl group,
- R′ and R″ each independently represent a hydrogen atom, a halogen atom or a C1-C4 alkyl group, and
- A represents a 5- or 6-membered aromatic ring of formula:
- wherein:
- X represents a nitrogen, oxygen or sulfur atom,
- Y represents a carbon atom or a single bond,
- Z1, Z2 and Z3 each independently represent a carbon or nitrogen atom, and
- R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C1-C4 alkyl group, a hydroxyl group, a C1-C4 alkoxy group, a trifluoromethyl group or a dialkylamino group;
- or
- R1 and R2 together with the atoms of the heterocycle to which they are attached form an aromatic ring comprising 6 carbon atoms, whereby A represents a fused bicyclic group,
- b) addition salts thereof.
11 more elements
Dependencies are inferred from the claim text.