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US 8,013,008 B2Granted
Cyclic amine compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsAtsushi Hasuoka, Satoshi Yamamoto
Life of this patent
Estimating the term…
Abstract
A compound represented by the formula (I) each symbol of which is defined in the specification, or a salt thereof which has a superior androgen receptor regulating activity.
Claims8
A compound represented by the formula (I)
- wherein
- R1 is a hydrogen atom or alkyl optionally having substituent(s);
- R2 is a hydrogen atom, a halogen atom, alkyl optionally having substituent(s) or alkoxy optionally having substituent(s);
- R3 is cyano;
- R4 is a hydrogen atom or a halogen atom;
- R5 is a hydrogen atom;
- R6 is a hydrogen atom;
- R7 is alkyl optionally having substituent(s);
- R8 is a hydrogen atom, alkyl optionally having substituent(s), alkenyl optionally having substituent(s) or cycloalkyl optionally having substituent(s);
- R9 is hydroxy;
- and
- ring A is a 5- or 6-membered ring optionally having substituent(s) other than R6 to R9 (except 2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-3-methylbenzonitrile, 2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]benzonitrile, 4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]benzonitrile, 2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-5-methylbenzonitrile, 2-chloro-3-ethyl-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]benzonitrile, 4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, 4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-3-(trifluoromethyl)benzonitrile, 4-[(2S,3S)-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, 4-[(2S,3R)-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, and 2-chloro-4-[(2S)-3-hydroxy-2-methylpiperidin-1-yl]benzonitrile), or a salt thereof.
9 more elements
A compound below or a salt thereof:
- 2-fluoro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]benzonitrile, 2-fluoro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1 -yl]-3-methylbenzonitrile, 4-[(2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidin-1-yl]-2,6-difluorobenzonitrile, 2-chloro-4-[(2S,3S)-3-hydroxy-2-methyl-3-(trifluoromethyl)pyrrolidin-1 -yl]benzonitrile, 2,6-difluoro-4-[(2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidin-1-yl]benzonitrile, or 4-[(2S,3R)-3-cyclopropyl-3-hydroxy-2-methylpyrrolidin-1 -yl]-2-fluorobenzonitrile.
Dependencies are inferred from the claim text.