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US 8,013,007 B2Granted
Alpha 1A-adrenoceptor antagonists
AssigneeConcert Pharmaceuticals, Inc.
InventorJulie F. Liu
Life of this patent
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Abstract
This invention relates to novel compounds that are dihydroindoles derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel dihydroindoles derivatives that are derivatives of silodosin. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an α-1A-adrenoreceptor antagonist, such as silodosin.
Claims30
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- each R is independently selected from hydrogen or deuterium;
- and
- at least one R is deuterium;
- each deuterium present at a site designated as a site of deuteration is present at an isotopic enrichment of at least 500;
- and
- wherein (a) R4a and R4b are simultaneously deuterium (b) R4a and R5b are simultaneously deuterium and (c) R6a and R6b are simultaneously deuterium.
4 more elements
Dependencies are inferred from the claim text.