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US 8,012,996 B2Granted
Methods and composition for inhibition of angiogenesis
AssigneeChildren's Medical Center Corporation
InventorRobert D'Amato
Life of this patent
Estimating the term…
Abstract
The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as EM-12 and its derivatives have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Importantly, these compounds can be administered orally.
Claims8
A method of reducing undesired angiogenesis associated with a condition in a human or animal comprising administering to the human or animal with undesired angiogenesis a composition comprising an effective amount of a compound of the following formula:
- and a pharmaceutically acceptable carrier or excipient, wherein the condition is vein occlusion, artery occlusion, carotid obstructive disease, polyarteritis, atherosclerosis, Osler-Webber-Rendu disease, or sickle cell anemia.
Dependencies are inferred from the claim text.