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US 8,012,993 B2Granted
Stable S-nitrosothiols, method of synthesis and use
AssigneeLacer, S.A.
InventorsJosé Repollés Moliner, Francisco Pubill Coy, Marisabel Mourelle Mancini, Juan Carlos del Castillo Nieto, Lydia Cabeza Llorente, Juan Martínez Bonín, Ana Modolell Saladrigas
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Abstract
The present invention relates to stable S-nitrosothiols derivatives of formula (I) having vasodilating effect and which inhibit the aggregation of the platelets and which therefore are useful for the preparation of medicaments for treatment of NO related diseases. The invention also relates to a process for the synthesis of the compounds of formula (I).
Claims17
A compound of formula (I)
- wherein
- R1 and R3 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl and alkynyl;
- R2, R4, R5, R6, R7 and R8 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl and alkynyl;
- R9 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, alkynyl, aryl and aralkyl;
- R10 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, heterocyclyl, —C(═O)R11 and —S(═O)2R11, wherein R11 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, alkynyl, aryl, aralkyl and heterocyclyl;
- Z is NO;
- Y is an alkoxycarbonyl of formula —C(═O)OR12, wherein R12 is selected from the group consisting of alkyl, alkenyl, cycloalkyl, alkynyl, aryl, aralkyl, and heterocyclyl;
- and
- X is —NR13;
- wherein R13 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, alkynyl, aryl, aralkyl and heterocyclyl;
- or its salts thereof.
8 more elements
Dependencies are inferred from the claim text.