Compounds and their uses 707

A compound of formula (I):

• wherein:
• R1 is selected from H, (C1-C6)alkyl, (C2-C6)alkenyl, (C3-C6)alkynyl, (CH2)a—X—Ar and (CR101R102)a—X—Ar wherein said (C1-C6)alkyl is optionally substituted with 1, 2 or 3 groups independently selected from —(C1-C6)alkoxy, -halo, —OH, -heterocycloalkyl, (C3-C7)cycloalkyl, and —NR8R9;
• R2 and R3 are independently selected from H, halo, (C1-C6)alkyl, (C1-C6)alkoxy and (CH2)d—Y;
• wherein said (C1-C6)alkyl is optionally substituted with 1, 2 or 3 groups independently selected from —(C1-C6)alkoxy, -halo and —OH;
• and wherein said (C1-C6)alkoxy is optionally substituted with 1, 2 or 3 groups independently selected from -halo and —OH;
• and provided that when R2 is (CH2)d—Y, R3 is selected from H, halo, (C1-C6)alkyl and (C1-C6)alkoxy;
• and provided that when R3 is (CH2)d—Y, R2 is selected from H, halo, (C1-C6)alkyl and (C1-C6) alkoxy;
• R4 and R5 are independently selected from H, (C1-C6)alkyl, (C1-C6)alkoxy, halo, CF3, and CN;
• R6 is selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C3-C7)cycloalkyl, aryl, heteroaryl and OH, wherein said (C1-C6)alkyl, (C1-C6)alkoxy, (C3-C7)cycloalkyl, aryl or heteroaryl group may be substituted by 1 or more halo atoms;
• R7 is selected from H, (C1-C6)alkyl, (C1-C6)alkoxy and halo;
• Ar is an aryl or heteroaryl ring optionally substituted with 1, 2 or 3 groups independently selected from —(C1-C6)alkyl, —(C2-C6)alkenyl, —(C3-C6)alkynyl, —(CH2)e—O—(C1-C6)alkyl, —(CH2)e—S(O)f—(C1-C6)alkyl, —(CH2)e—N(R10)—(C1-C6)alkyl, —(CH2)e-Z-(C1-C6)alkyl, —O-heterocycloalkyl, —S—(O)b-heterocycloalkyl, —N(R11)-heterocycloalkyl, —CN, —OH, -halo, -phenyl, -heterocycloalkyl, —(C3-C7)cycloalkyl, —C(O)NR8R9, —NR8R9, —C(O)OH and C(O)NR10SO2—(C1-C6)alkyl, wherein each occurrence of (C1-C6)alkyl is, independently, optionally substituted with 1, 2 or 3 groups independently selected from -halo, —OH, —(C1-C6)alkoxy, —NR12R13 and heterocycloalkyl;
• X is selected from a single bond, O, NR14 and S(O)g;
• Y is selected from heterocycloalkyl, O-heterocycloalkyl, O—(CH2)h—NR16R17, NR18—(CH2)h—NR16R17, S—(O)j-heterocycloalkyl, S—(O)j—(CH2)h—NR16R17, NR16R17, NR15C(O)R16, NR15SO2R16, C(O)NR16R17, OC(O)NR16R17, OC(O)R16, C(O)OR16 and NR15C(O)OR16;
• Z is selected from C(O)N(R18), N(R18)C(O), C(O)O, OC(O), SO2N(R18), N(R18)SO2, OC(O)N(R18), N(R18)C(O)O, and OC(O)O;
• R8 and R9 are independently selected from H and (C1-C6)alkyl, wherein said (C1-C6)alkyl is optionally substituted with 1, 2 or 3 groups independently selected from —(C1-C6)alkoxy, -halo, —OH and NR19R20;
• or R8 and R9 together with the nitrogen atom to which they are attached form a 3 to 7 membered ring, optionally containing a further heteroatom selected from NR21, S and O;
• and optionally containing, where possible, 1 or 2 double bonds;
• wherein said ring is optionally substituted on carbon by 1 or 2 substituents independently selected from —(C1-C6)alkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, —OH, —CN, halo and —NR19R20;
• R12 and R13 are independently selected from H and (C1-C6)alkyl wherein said (C1-C6)alkyl is optionally substituted with —(C1-C6)alkoxy, —OH, -halo, —(C3-C7)cycloalkyl and —NR22R23;
• or R12 and R13 together with the nitrogen atom to which they are attached form a 3 to 7 membered ring, optionally containing a further heteroatom selected from NR24, S and O;
• and optionally containing, where possible, 1 or 2 double bonds;
• wherein said ring is optionally substituted on carbon by 1 or 2 substituents independently selected from —(C1-C6)alkyl, (C1-C6) alkoxy, (C2-C6)alkenyl, —OH, —CN, halo and —NR22R23;
• R16 is selected from H, (C1-C6)alkyl and heterocycloalkyl, wherein said (C1-C6)alkyl is optionally substituted with —(C1-C6)alkoxy, —OH, -halo, —(C3-C7)cycloalkyl and —NR25R26;
• R17 is selected from H and (C1-C6)alkyl;
• or R16 and R17 together with the nitrogen atom to which they are attached form a 3 to 7 membered ring, optionally containing a further heteroatom selected from NR27, S and O;
• and optionally containing, where possible, 1 or 2 double bonds;
• wherein said ring is optionally substituted on carbon by 1 or 2 substituents independently selected from —(C1-C6)alkyl, (C1-C6) alkoxy, (C2-C6)alkenyl, —OH, —CN, halo and —NR25R26, wherein said —(C1-C6)alkyl is optionally substituted by —OH;
• R25 and R26 are independently selected from H and (C1-C6)alkyl wherein said (C1-C6)alkyl is optionally substituted with —(C1-C6)alkoxy, —OH, -halo, —(C3-C7)cycloalkyl and —NR22R23;
• or R25 and R26 together with the nitrogen atom to which they are attached form a 3 to 7 membered ring, optionally containing a further heteroatom selected from NR24, S and O;
• and optionally containing, where possible, 1 or 2 double bonds;
• wherein said ring is optionally substituted on carbon by 1 or 2 substituents independently selected from —(C1-C6)alkyl, (C1-C6) alkoxy, (C2-C6)alkenyl, —OH, —CN, halo and —NR22R23;
• R27 is selected from H, (C1-C6)alkyl and heterocycloalkyl, wherein said (C1-C6)alkyl is optionally substituted by a substituent selected from —OH, -halo and —NR22R23;
• R10, R11, R14, R15, R18, R19, R20R21, R22, R23 and R24 are independently selected from H and (C1-C6)alkyl;
• a is selected from 0, 1, 2, 3, 4, 5 and 6;
• d, e and h are independently selected from 0, 1, 2 and 3;
• b, f, g and j are independently selected from 0, 1 and 2;
• heterocycloalkyl is a C-linked 3 to 7 membered non-aromatic cyclic ring, containing from 1 to 2 NR28 atoms, or one NR28 atom and an S or an O atom, or one S atom, or one O atom;
• optionally containing, where possible, 1 or 2 double bonds;
• which unless otherwise stated, may be optionally substituted with 1 to 3 substituents independently selected from (C1-C6) alkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, —OH, —CN, halo and —NR29R30, wherein said —(C1-C6) alkyl is optionally substituted by —OH;
• heteroaryl is a 5, 6, 9 or 10 membered aromatic ring, containing from 1 to 2 N atoms and, optionally, an NR31 atom, or one NR31 atom and an S or an O atom, or one S atom, or one O atom;
• which, unless otherwise stated, may be optionally substituted with 1-3 substituents independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, —OH, —CN, halo and —NR38R39;
• cycloalkyl is a non-aromatic carbocyclic ring containing the requisite number of carbon atoms, optionally containing, where possible, up to 3 double bonds;
• which, unless otherwise stated, may be optionally substituted with 1 to 3 substituents independently selected from (C1-C6) alkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, —OH, —CN, halo and —NR34R35;
• aryl is an aromatic ring containing 6 or 10 carbon atoms;
• which unless otherwise stated, may be optionally substituted with 1 to 3 substituents independently selected from (C1-C6)alkyl, (C1-C6) alkoxy, (C2-C6)alkenyl, —OH, —CN, halo and —NR36R37;
• R28 and R31 are each independently selected from H, (C1-C6)alkyl and —C(O)O—(C1-C6)alkyl, wherein said (C1-C6)alkyl may be optionally substituted with (C1-C6)alkoxy, —OH, halo, (C3-C7) cycloalkyl and —NR32R33;
• R29, R30, R32 and R33 are each independently selected from H and (C1-C6)alkyl;
• R34, R35, R36, R37, R38 and R39 are each independently selected from H, and (C1-C6)alkyl;
• R101 is (C1-C6)alkyl;
• R102 is H or (C1-C6)alkyl;
• or a pharmaceutically acceptable salt or N-oxide thereof.