Prodrugs of CC-A1065 analogs

A prodrug of the following formula:

• in which Y represents a leaving group selected from the group consisting of a halide, methanesulfonate, para-toluenesulfonate, trifluoromethane sulfonate, mono nitro and dinitro phenolate;
• wherein R, R′, R1, R2 and R6 are each independently hydrogen, C1-C3 linear alkyl, methoxy, hydroxyl, primary amino, secondary amino, tertiary amino, or amido or a linker that provides for linkage of the prodrug to a cell binding agent, provided that at least one of R, R′, R1, R2 and R6 is a linker;
• and wherein R7 is a sulfonic acid containing phenyl carbamate of formula XII:
• where R9 is H or a branched, cyclic or linear alkyl;
• R10, R11, R12 and R13 are identical or different with at least one being a —X—SO3−M+ group with M+ being H+ or the cation deriving from an atom of the IA group, and X being a direct link, or a spacer chosen from C1 to C4 linear or branched alkyl, alkenyl, alkynyl, —O-alkyl, —S-alkyl or aminoalkyl and the other R10, R11, R12 or R13 being H, a C1-C6 branched or linear alkyl, —O-alkyl, —S-alkyl, hydroxyl, primary amino, secondary amino, or amido, halide, nitro, or azido;
• or an optical isomer, racemate, diastereomer or enantiomer of such prodrug, or a pharmaceutically acceptable salt of such prodrug, optical isomer, racemate, diastereomer or enantiomer.