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US 8,012,970 B2Granted
Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine, synthesis process and uses thereof
AssigneeUniversta' Degli Studi di Siena
InventorsMariangela Biava, Fabrizio Manetti, Delia Deidda, Raffaello Pompei, Maurizio Botta, Giulio Cesare Porretta
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Abstract
The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
Claims22
Compounds having general formula I:
- wherein
- X is N;
- Y is CH;
- R is morpholinyl,
- R1 is p-methylphenyl, p-ethylphenyl, p-propylphenyl, p-isopropylphenyl, p-methoxyphenyl, o-fluorophenyl;
- and
- R2 is methyl.
4 more elements
Compounds having general formula II
- wherein
- X is N;
- Y is CH;
- R is morpholinyl;
- R1 is o-fluorophenyl, p-methylphenyl, p-ethylphenyl, p-propylphenyl, p-isopropylphenyl, p-methoxyphenyl;
- R2 is methyl.
3 more elements
Dependencies are inferred from the claim text.