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US 8,012,969 B2Granted
11C-labeled benzyl-lactam compounds and their use as imaging agents
AssigneeGe Healthcare Limited
InventorsChristopher John Helal, Gunnar Antoni, Bengt Langstrom, Jia Zhi Sheng, Susan Beth Sobolov-Jaynes, Timothy James McCarthy
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Abstract
The invention relates to “C-labeled compounds, their preparation, compositions comprising an effective amount of a “C-labeled compound, and the use of a “C-labeled compound as a radiopharmaceutical for positron emission tomography.
Claims15
A compound of formula I:
- or a pharmaceutically acceptable salt thereof,
- wherein
- X is CH or N;
- Y is —C(OR1)(R2)2 or —N(R3)2;
- R1 is H or C1-C6 alkyl;
- each R2 is independently C1-C6 alkyl, or both R2 groups are taken together form —(CH2)n—, where n is an integer ranging from 2 to 7;
- each R3 is independently C1-C6 alkyl, or both R3 groups are taken together to form —(CH2)2—O—(CH2)2—, —(CH2)2—(NR4)—(CH2)2— or —(CH2)m—, where m is an integer ranging from 2 to 7;
- R4 is H or CH3;
- and
- * is a chiral carbon atom, wherein the carbon is a racemate, an (R)-enantiomer, an (S) -enantiomer, or a mixture thereof.
7 more elements
Dependencies are inferred from the claim text.