Diaminopyrimidinecarboxamide derivative

A solid pharmaceutical composition comprising a compound of a formula (I):

• wherein:
• A1:
• CH,
• A2:
• CH,
• R3:
• —R0, -halogen, or -hetero ring;
• R0:
• the same or different from one another, and each is H or a lower alkyl,
• n:
• 0,
• R4:
• —H, -lower alkyl substituted with halogen, —OH, —NH—CHO, —CON(R0)2, -lower alkylene substituted with halogen-OH, -lower alkylene-NH2, -lower alkylene-NHCONH2, -lower alkylene-CO2H, -lower alkylene-CO2-lower alkyl, -lower alkylene-CN, or —CH(lower alkylene-OH)2, or a group represented by a formula —Xa—R4a,
• Xa:
• single bond, —O—, —CO—, —S—, —SO2—, —N(R0)—N(R0)CO—, —N(R0)SO2—, -lower alkylene-O—, ,-lower alkylene-N(R0)—, -lower alkylene-N(R0)CO—, -lower alkylene-N(R0)SO2—, -lower alkylene-N(R0)CO2—, —N(CO—R0)—, —N(SO2-lower alkyl)-, —CON(R0)—, -lower alkylene-O—CO—, -lower alkenylene-CO—, -lower)alkenylene-CON(R0)—, -lower alkenylene-CO2—, —O—(CH2)k-cycloalkylene-(CH2)m—, —N(R0)—(CH2)k-cycloalkylene-(CH2)m—, —CO—(CH2)k-cycloalkylene-(CH2)m—, —CON(R0)—(CH2)k-cycloalkylene-(CH2)m— or —N(R0)CO—(CH2)k-cycloalkylene-(CH2)m—,
• k and m, the same or different from each other, and each is 0, 1, 2, 3 or 4,
• R4a:
• lower alkyl, phenyl, hetero ring, cycloalkyl, lower alkylene-phenyl, lower alkylene-hetero ring, lower alkylene-OH, lower alkenyl, lower alkenylene-phenyl or lower alkenylene-hetero ring,
• wherein the hetero rings in R3 and R4a may be substituted with 1 to 5 of lower alkyl, halogen, —OR0, —S-lower alkyl, —S(O)-lower alkyl, —SO2-lower alkyl, lower alkylene-OR0, —N(R0)2, —CO2R0, —CON(R0)2, —CN, —CHO, —SO2N(R0)2, —N(R0)—SO2-lower alkyl, —N(R0) —CO—N(R0)2, —N(R0)—CO2-lower alkyl, —N(R0)—CO2-cycloalkyl, —NH—C(═NH)—NH-lower alkyl, —NH—C(═N—CN)—NH-lower alkyl, hetero ring (said hetero ring may be substituted with 1 to 5 substituents selected from lower alkyl, OH and lower alkylene-OH), -lower alkylene-NH—C(═NN)—NH2, —O-phenyl, —CO-phenyl, —N(R0)—CO-lower alkyl, —N(R0)—CO-lower alkylene-N(R0)2, -lower alkylene-N(R0)—CO-lower alkylene-N(R0)2, —CO—N(R0)-lower alkylene-N(R0)2, —CO-lower)alkylene-N(R0)2, —CO-lower alkylene-CO2R0, -lower alkylene-N(R0)2, -lower alkylene-CO2R0, -lower)alkylene-CO—N(R0)2, -lower alkylene-N(R0)—CO-lower alkyl, -lower alkylene-N(R0)—CO2-lower alkyl, -lower alkylene-N(R0)—SO2-lower alkyl,-lower alkylene-hetero ring (said hetero ring may be substituted with 1 to 5 substituents selected from lower alkyl, OH and lower alkylene-OH), -lower alkylene-O-lower alkylene-phenyl,
• ═N—O—R0 or oxo, and phenyl and cycloalkyl may be substituted with 1 to 5 of lower alkyl, OH, O-lower alkyl or N(R0)2, and
• wherein the lower alkylene in R3, R4, R4a and Xa may be substituted with 1 to 5 of —OR0, —CO2R0, —CON(R0)2, —N(R0)2, —N(R0)COR0 or hetero ring, or
• R3 and R4 may together form *—N(R7)—(CH2)2—, *—(CH2)2—N(R7)—, *—CH2—N(R7)—CH2—, *—N(R7)—(CH2)3—, *—(CH2)3—N(R7)—, *—CH2—N(R7)—(CH2)2—, *—(CH2)2—N(R7)—CH2—, *—C(O)—N(R7)—(CH2)2—, *—(CH2)2—N(R7)—C(O)—, *—N(R7)—CH═CH—, *—CH═CH—N(R7)—,
• *—N═CH—CH═CH—, *—CH═N—CH═CH—, *—CH═CH—N═CH—, *—CH═CH—CH═N—, *—N═CH—CH═N—, *—CH═N—N═CH—, *—N(R7)—N═CH—, *—CH═N—N(R7)—, *—O—CH2—O—, *—O—(CH2)2—O—, *—O—(CH2)3—O—, *—O—(CH2)2—N(R7)—, *—(CH2)2—C(O)—, *—CH═CH—C(O)—O— or *—N═C(CF3)—NH—,
• wherein * indicates bonding to the position shown by R3,
• R7:
• —H, -lower alkyl or —CO-lower alkyl,
• B:
• cycloalkyl which may have a substituent(s),
• Y:
• single bond;
• and
• R1 and R2:
• H;
• or a salt thereof;
• and a pharmaceutically acceptable carrier.