Tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulators

A compound having a structure according to formula (I):

• or a sal thereof wherein
• the dashed lines between positions 2-3 and positions 3a-8a in formula (I) represent locations for each of two double bonds present when X1R1 is present;
• the dashed lines between positions 3-3a and positions 8a-1 in formula (I) represent locations for each of two double bonds present when X2R2 is present;
• the dashed line between position 8 and X8R8 in formula (I) represents the location for a double bond;
• X1 is absent or lower alkylene;
• X2 is absent or lower alkylene;
• wherein only one of X1R1 and X2R2 are present;
• X3 is absent, lower alkylene, lower alkylidene or —NH—;
• X4 is absent or lower alkylene;
• X5 is absent or lower alkylene;
• X6 is absent or lower alkylene;
• X7 is absent or lower alkylene;
• when the dashed line between position 8 and X8R8 is absent, X8 is absent or is lower alkylene;
• when the dashed line between position 8 and X8R8 is present, X8 is absent;
• R1 is selected from hydrogen, alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), alkylsulfonyl, aryl, C3-C12 cycloalkyl or heterocyclyl, wherein aryl, C3-C12 cycloalkyl or heterocyclyl is each optionally substituted at one or more positions by halogen, aminosulfonyl, alkylaminosulfonyl,alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), hydroxy or lower alkoxy;
• R2 is selected from hydrogen, alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), alkylsulfonyl, aryl, C3-C12 cycloalkyl or heterocyclyl, wherein aryl, C3-C12 cycloalkyl or heterocyclyl is each optionally substituted at one or more positions by halogen, aminosulfonyl, alkylaminosulfonyl, alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), hydroxy or lower alkoxy;
• R3 is —C(O)-Z1(R9), —SO2—NR10-Z2(R11) or —C(O)—NR12-Z3(R13);
• R4 is hydrogen, halogen, alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), hydroxy or lower alkoxy;
• R5 is hydrogen, halogen, alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), hydroxy or lower alkoxy;
• R6 is hydrogen, aminoalkyl, alkylaminoalkyl, alkyl (optionally substituted at one or more positions by halogen, hydroxy or alkoxy), formyl, alkylcarbonyl, arylcarbonyl, heterocyclylcarbonyl, arylalkylcarbonyl, carboxy, alkoxycarbonyl, arylalkoxycarbonyl, aminocarbonyl, alkylamimocarbonyl, alkylsulfonyl, aminosulfonyl, alkylaminosulfonyl, aryl, arylsulfonyl (optionally substituted on aryl at one or more positions by alkyl, halogen, hydroxy or alkoxy) or heterocyclyl;
• R7 is hydrogen, halogen, alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), hydroxy or lower alkoxy;
• when the dashed line between position 8 and X8R8 is absent, X8 is absent or is lower alkylene and R8 is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, aryl, C3-C12 cycloalkyl or heterocyclyl, wherein aryl, C3-C12 cycloalkyl or heterocyclyl is each optionally substituted at one or more positions by hydroxy, oxo, lower alkyl, lower alkoxy or halogen;
• when the dashed line between position 8 and X8R8 is present, X8 is absent and R8 is CH-aryl or CH-heterocyclyl, wherein aryl or heterocyclyl is each optionally substituted at one or more positions by hydroxy, oxo, lower alkyl, lower alkoxy or halogen;
• R9 is aryl, C3-C12 cycloalkyl or heterocyclyl each optionally substituted by one or more hydroxy, oxo, halogen, amino, alkylamino, aminoalkyl, alkylaminoalkyl, alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), alkoxy (optionally substituted at one or more positions by halogen or hydroxy), carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, aryl, aryloxy, arylalkoxy or heterocyclyl;
• R10 is hydrogen or lower alkyl;
• R11 is hydrogen, aryl, C3-C12 cycloalkyl or heterocyclyl, wherein aryl, C3-C12 cycloalkyl or heterocyclyl is each optionally substituted by one or more hydroxy, oxo, halogen, amino, alkylamino, aminoalkyl, alkylaminoalkyl, alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), alkoxy (optionally substituted at one or more positions by halogen or hydroxy), carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, aryl, aryloxy, arylalkoxy or heterocyclyl;
• R12 is hydrogen, lower alkyl or alkylcarbonyl;
• R13 is hydrogen or is aryl, C3-C12 cycloalkyl or heterocyclyl each optionally substituted by one or more hydroxy, oxo, halogen, amino, alkylamino, aminoalkyl, alkylaminoalkyl, alkyl (optionally substituted at one or more positions by halogen, hydroxy or lower alkoxy), alkoxy (optionally substituted at one or more positions by halogen or hydroxy), carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, aminosulfonyl, alkylaminosulfonyl, aryl, aryloxy, arylalkoxy or heterocyclyl;
• Z1 and Z2 are each absent or alkyl;
• and,
• Z3 is absent, —NH—, —SO2- or alkylene (wherein alkyl is optionally substituted at one or more positions by halogen, hydroxy, lower alkoxy, carboxy or alkoxycarbonyl).