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US 8,012,951 B2Granted
7-N-substituted phenyl tetracycline compounds
AssigneeTrustees of Tufts College
InventorsMark L. Nelson, Darrell J. Koza
Life of this patent
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Abstract
7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
Claims26
A 7-substituted tetracycline compound of the formula:
- wherein:
- R4 and R4′ are each alkyl;
- R5 is hydrogen, hydroxyl, or a prodrug moiety;
- R6 and R6′ are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl;
- R7 is an N-substituted phenyl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
A method for treating a bacterial infection in a mammal, comprising administering to said mammal a 7-substituted tetracycline compound of formula (I):
- wherein:
- R4 and R4′ are each alkyl;
- R5 is hydrogen, hydroxyl, or a prodrug moiety;
- R6 and R6′ are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl;
- R7 is an N-substituted phenyl;
- or a pharmaceutically acceptable salt thereof,
- such that the bacterial infection is treated.
4 more elements
Dependencies are inferred from the claim text.