Anti-angiogenic methods and compositions
AssigneeSangamo BioSciences, Inc.
InventorsH. Steve Zhang, Philip D. Gregory, Edward J. Rebar
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Abstract
Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
Claims10
A method for the treatment of a malignancy in a human or a mouse animal, wherein the method comprises introducing a fusion protein comprising a zinc finger protein and an activation domain into the malignancy of the human or a mouse animal having a genome, the genome comprising a target site within a pigment epithelium derived factor (PEDF) gene, whereby the zinc finger protein binds to the target site and thereby activates PEDF expression in the human or a mouse animal such the malignancy is treated, and further wherein the zinc finger protein binds to a target site specified in Table 1 (SEQ ID NOs:8-13).
Dependencies are inferred from the claim text.