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US 8,012,944 B2Granted
Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
AssigneePharmascience Inc.
InventorsEric LaCasse, Daniel McManus, Jon P. Durkin
Life of this patent
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Abstract
The invention features methods, compositions, and kits for treating a patient having a proliferative disease.
Claims35
A method of treating cancer in a patient, said method comprising administering to said patient:
- (i) an antisense IAP nucleobase oligomer of between eight and thirty nucleobases in length, the nucleobase oligomer consisting of 5′-NGCACCCNGGANACCANNN-3′ (SEQ ID NO:
- 151), wherein “N” is “T” or “U” or at least eight consecutive nucleobases thereof;
- and
- (ii) BAY-43-9006, in amounts that together are sufficient to treat said patient.
1 more element
A method of treating cancer in a patient, said method comprising administering to said patient:
- (i) an antisense IAP nucleobase oligomer comprising 5′-NGCACCCNGGANACCANNN-3′ (SEQ ID NO:
- 151), wherein “N” is “T” or “U”;
- and
- (ii) BAY-43-9006, in amounts that together are sufficient to treat said patient.
1 more element
A method of enhancing apoptosis of a cell, the method comprising contacting a cell with a composition comprising:
- (i) an antisense IAP nucleobase oligomer of between eight and thirty nucleobases in length, the nucleobase oligomer consisting of 5′-NGCACCCNGGANACCANNN-3′(SEQ ID NO:
- 151), wherein “N” is “T” or “U” or at least eight consecutive nucleobases thereof;
- and (ii) BAY-43-9006, whereby apoptosis is enhanced.
Dependencies are inferred from the claim text.