Macrocyclic inhibitors of hepatitis C virus

A compound having the formula

• a N-oxide, salt, or stereoisomer thereof, wherein
• X is N, CH and where X bears a double bond it is C;
• R1 is —OR5, —NH—SO2R6;
• R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl;
• R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, or C3-7cycloalkyl;
• R4 is isoquinolinyl optionally substituted with one, two or three substituents each independently selected from C1-6alkyl, C1-6alkoxy, hydroxy, halo, polyhalo-C1-6alkyl, polyhaloC1-6alkoxy, amino, mono- or diC1-6alkylamino, mono- or diC1-6alkylaminocarbonyl, C1-6alkylcarbonyl-amino, aryl, and Het;
• n is 3, 4, 5, or 6;
• wherein each dashed line (represented by - - - - -) represents an optional double bond;
• R5 is hydrogen;
• aryl;
• Het;
• C3-7cycloalkyl optionally substituted with C1-6alkyl;
• or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;
• R6 is aryl;
• Het;
• C3-7cycloalkyl optionally substituted with C1-6alkyl;
• or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;
• each aryl as a group or part of a group is phenyl optionally substituted with one, two or three substituents selected from halo, hydroxy, nitro, cyano, carboxyl, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkylcarbonyl, amino, mono- or diC1-6alkylamino, azido, mercapto, polyhaloC1-6alkyl, polyhaloC1-6alkoxy, cyclopropyl, pyrrolidinyl, piperidinyl, piperazinyl, 4-C1-6alkylpiperazinyl,
• 4-C1-6alkylcarbonylpiperazinyl, and morpholinyl;
• and wherein the morpholinyl and piperidinyl groups may optionally substituted with one or two C1-6alkyl radicals;
• and
• each Het as a group or part of a group is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms each independently selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, carboxyl, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkylcarbonyl, amino, mono- or diC1-6alkylamino, azido, mercapto, polyhaloC1-6alkyl, polyhaloC1-6alkoxy, C3-7cycloalkyl, pyrrolidinyl, piperidinyl, piperazinyl, 4-C1-6alkyl-piperazinyl,
• 4-C1-6alkylcarbonyl-piperazinyl, and morpholinyl and wherein the morpholinyl and piperidinyl groups may optionally substituted with one or two C1-6alkyl radicals.