Dermatological and/or cosmetic composition containing polypeptides
AssigneeISP Investments Inc.
InventorsClaude Dal Farra, Nouha Domloge, Jean-Marie Botto
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Abstract
The present invention relates to the use of proteins of the UCP family, or UCP protein polypeptide or peptide fragments, as an active agent, alone or in association with at least one other active agent, in or for the preparation of a pharmaceutical and/or dermatological and/or cosmetic composition. The invention also relates to any composition containing the aforementioned active ingredient, as well as its use as a slimming agent.
Claims23
A composition comprising a protein fragment of the uncoupling protein (UCP) family as an active ingredient, wherein the protein fragment is a synthetic peptide of the following formula:
- (AA)n-Pro-X1-X2-X1-X3-Lys-X1-Arg-X4-X5-(AA)n (SEQ ID NO:
- 10), wherein
- X1=Leu, Thr, or Val,
- X2=Asp, or Glu,
- X3=Ala, or Val,
- X4=Leu, Phe, or Tyr,
- X5=Gln, Ile, or Met,
- (AA) is any amino acid, and
- n is a whole number ranging from 0 to 2;
- and wherein said protein fragment comprises a synthetic peptide selected from the group consisting of:
- 1)
- Pro Leu Asp Thr Ala Lys Val Arg
- (SEQ ID NO:
- 1)
- Leu Gln,
- 2)
- Pro Thr Glu Val Ala Lys Val Arg
- (SEQ ID NO:
- 2)
- Phe Gln,
- 3)
- Pro Thr Asp Val Ala Lys Val Arg
- (SEQ ID NO:
- 3)
- Leu Gln,
- 4)
- Pro Thr Glu Val Ala Lys Val Arg
- (SEQ ID NO:
- 4)
- Leu Gln,
- 5)
- Pro Thr Asp Val Ala Lys Val Arg
- (SEQ ID NO:
- 5)
- Phe Gln,
- 6)
- Pro Val Asp Val Val Lys Thr Arg
- (SEQ ID NO:
- 6)
- Phe Ile,
- 7)
- Pro Val Asp Val Val Lys Thr Arg
- (SEQ ID NO:
- 7)
- Tyr Met,
- 8)
- Pro Val Asp Val Val Lys Thr Arg
- (SEQ ID NO:
- 8)
- Phe Met,
- and
- 9)
- Pro Val Asp Val Val Lys Thr Arg
- (SEQ ID NO:
- 9)
- Tyr Ile.
Dependencies are inferred from the claim text.