Small peptides and methods for treatment of inflammation
AssigneeMowycal Lending, LLC
InventorsJohn C. Houck, James Clagett
Life of this patent
Estimating the term…
Abstract
Methods for treating cutaneous inflammation are described. Also described is a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
Claims3
A method for treating cutaneous inflammation in a mammal, the method comprising administering to the mammal an anti-inflammatory effective amount of a peptide having the formula f-Met-Leu-X where X (SEQ ID NOs:
- 1, 2 and 3) is selected from the group consisting of Tyr, Tyr-Phe (SEQ ID NO:
- 1), Phe-Phe (SEQ ID NO:
- 2) and Phe-Tyr (SEQ ID NO:
- 3).
A method for treating cutaneous inflammation in a mammal, the method comprising administering to the mammal an anti-inflammatory effective amount of a peptide having the formula f-Met-Leu-X where X (SEQ ID NOs:
- 1, 2 and 3) is selected from the group consisting of Tyr, Tyr-Phe (SEQ ID NO:
- 1), Phe-Phe (SEQ ID NO:
- 2) and Phe-Tyr (SEQ ID NO:
- 3), wherein the cutaneous inflammation is selected from the group consisting of dermatitis, eczema, psoriasis, contact dermatitis, sunburn and aging.
Dependencies are inferred from the claim text.