Agent for inducing apoptosis comprising MSX1 or a gene encoding the same as an active ingredient
AssigneeSungkyunkwan University Foundation for Corporate Collaboration
InventorsJe-Ho Lee, Kyoungsook Park
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Abstract
The present invention relates to a novel use of Msx1 protein or a nucleotide encoding the same for inducing apoptosis. The Msx1 of the present invention induces apoptosis through direct interaction with p53 via a homeodomain and such interaction leads to increased stability, and/or nuclear localization of p53 in cells. The Msx1 or homeodomain thereof can be effectively used for the treatment of tumors, in which wild-type p53 protein has lost its function by some mechanism that inactivates p53 proteins.
Claims12
A method of inducing apoptosis comprising a step of administering to a tissue or a subject associated with a disease condition selected from the group consisting of cervical cancer, ovarian cancer, and lung cancer, a therapeutically effective amount of Msx1 protein comprising SEQ ID NO:1 or comprising a homeodomain thereof, wherein the homeodomain consists of amino acid residues 239-298 of SEQ ID NO1.
A method of modulating p53 protein activity in a tissue or a subject comprising a step of administering to a tissue or a subject associated with a disease condition selected from the group consisting of cervical cancer, ovarian cancer, and lung cancer, a therapeutically effective amount of Msx1 protein comprising SEQ ID NO:1, or comprising a homeodomain thereof, wherein in the homeodomain consists of amino acid residues 239-298 of SEQ ID N01.
Dependencies are inferred from the claim text.