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US 8,012,737 B2Granted
Methods of producing influenza vaccine compositions
AssigneeMedImmune, LLC
InventorsQi Dang, Richard Schwartz
Life of this patent
Estimating the term…
Abstract
Methods and compositions for the optimization and production of influenza viruses, e.g., ca influenza B strains, in eggs and host cells suitable as influenza vaccines are provided.
Claims7
A method of increasing the yield of cold adapted reassortant influenza B virus particles, the method comprising:
- (a) introducing a plurality of cold adapted reassortant influenza B viruses into SPF embryonated hen eggs;
- (b) incubating the host eggs at a temperature of 31±0.5° C.;
- and,
- (c) recovering influenza virus particles from the host eggs,
- wherein the recovered virus particles resulting from the incubation has a yield which is greater than the yield resulting from an incubation of said cold adapted reassortant influenza B viruses in host eggs at 33° C.
2 more elements
Dependencies are inferred from the claim text.