Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use
AssigneeLudwig Institute for Cancer Research
InventorsKohei Miyazono, Takeshe Imamura, Peter ten Dijke
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Abstract
The invention relates to the molecule referred to as ALK-1, and its role as a type I receptor for members of the TGF-β family. The molecule has a role in the phosphorylation of Smad-5 and Smad1, which also act as activators of certain genes. Aspects of the invention relate to this interaction.
Claims8
A method for determining that an antibody which binds to the extracellular domain of ALK-1 inhibits TGF-β induced gene expression or Smad1 phosphorylation, comprising comparing TGF-β induced gene expression or Smad1 phosphorylation in a first sample of cells which express ALK-1, TGF-βRII and Smad1 that have been contacted with TGF-β, with TGF-β induced gene expression or Smad1 phosphorylation in a second sample of the same cells that have been contacted with TGFβ and said antibody.
Dependencies are inferred from the claim text.