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US 8,012,699 B2Granted
Recombinant antigens for diagnosis and prevention of murine typhus
AssigneeThe United States of America as represented by the Secretary of the Navy
InventorWei-Mei Ching
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Abstract
The invention relates to the construction of recombinant, immunodominant Rickettsia typhi proteins. The invention also relates to a method for the use of the recombinant proteins, either singly or in combination, in detection and diagnostic assays. The proteins can also be used in anti-Rickettsia typhi immunogenic formulations.
Claims5
A method of detecting R. typhi infection comprising the steps:
- a. exposing a primary OmpB reagent to patient sera, wherein said primary OmpB reagent is Fragment A consisting of amino acid sequence of SEQ ID NO:2 encoded by the nucleotide sequence of SEQ ID NO:1 or Fragment K consisting of amino acid sequence of SEQ ID NO:4 encoded by the nucleotide sequence of SEO ID NO:3;
- b. measuring bound antibody.
Dependencies are inferred from the claim text.