Methods of modulating metastasis and skeletal related events resulting from metastases
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsDeborah Lee Zimmerman, Rhonda Hansen, Jill Winter, Christoph Reinhard, Shuling Fang
Life of this patent
Estimating the term…
Abstract
The invention provides, inter alia, models of bone metastasis, methods for identifying agents that modulate skeletal related events and metastasis, methods for modulating skeletal related events and metastases, and methods for detecting skeletal related events and metastases. The methods and models generally comprise co-culturing cancer cells and host cells and comparing biological markers from such co-cultured cells to control cells.
Claims5
A method for determining the susceptibility of a cancer patient to an osteoblastic response in mesenchymal stem cells comprising detecting evidence of EphA2 expression in a patient's cancer sample, wherein the sample comprises cancer and host cells and wherein evidence of EphA2 expression is indicative of the patient's susceptibility to an osteoblastic response in mesenchymal stem cells.
Dependencies are inferred from the claim text.