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US 8,012,677 B2Granted
Evaluation and preservation solution
AssigneeXvivo Perfusion AB
InventorStig Steen
Life of this patent
Estimating the term…
Abstract
An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and coating compound, preferably dextran compounds and derivatives thereof having essentially the same structure at a concentration of 1-55 g/L weight, and a physiological serum concentration of salts and nutrients in a physiologically acceptable medium.
Claims38
A method of perfusing an organ, tissue, or part thereof, of an animal or human, the method comprising:
- evaluating the organ, tissue, or part thereof;
- and
- perfusing the organ, tissue, or part thereof at normothermia by recirculation with a solution,
- wherein the organ, tissue, or part thereof is connected to a heart-lung machine during the perfusion, and
- wherein the solution comprises:
- (a) serum albumin at a concentration of 55-105 g/L;
- (b) a scavenger and coating compound, which coats the capillary endothelium of the organ, tissue, or part thereof, at a concentration of 1-55 g/L;
- (c) a physiological serum concentration of a salt;
- and
- (d) a nutrient for the organ, tissue, or part thereof,
- in a physiologically acceptable medium;
- wherein the solution provides an oncotic pressure higher than an applied hydrostatic pressure in the organ, tissue, or part thereof, and
- wherein the solution prevents oedema formation.
10 more elements
Dependencies are inferred from the claim text.