Preservation of bioactive materials by spray drying
AssigneeMedImmune Vaccines, Inc.
InventorsVu Truong-Le, Binh Pham
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Abstract
This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form stable powder particles containing bioactive materials.
Claims6
A mixture of a high pressure gas with a suspension or solution, the mixture comprising:
- a high pressure gas, a bioactive material, a polyol, a polymer, and a surfactant, wherein the mixture forms stable powder particles on spraying and drying.
An article of manufacture comprising a container containing dried powder particles prepared by spray drying a mixture of high pressure gas with a suspension or solution of bioactive material, a polyol, a polymer, and a surfactant.
Dependencies are inferred from the claim text.