Tannate compositions, methods of making and methods of use
AssigneePernix Therapeutics, LLC
InventorsJeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
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Abstract
Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.
Claims14
A process for the conversion of at least one active pharmaceutical ingredient into a tannate salt complex for incorporation into a therapeutic liquid or semi-solid dosage form, the process comprising the steps of:
- (a) dissolving the salt or free base of the active pharmaceutical ingredient in a pharmaceutically acceptable liquid in the presence of a dispersing agent and tannic acid under stirring, to form a dispersion wherein the tannic acid component is of either a natural or synthetic source;
- (b) combining the tannate salt complex of the active pharmaceutical ingredient without isolation or purification with pharmaceutically acceptable excipients to generate a therapeutic dosage form.
A process for the conversion of at least one active pharmaceutical ingredient into a tannate salt complex for incorporation into a therapeutic solid dosage form, the process comprising mixing the salt or free base of the at least one active pharmaceutical ingredient, tannic acid, and a dispersing agent in a pharmaceutically acceptable liquid to form a tannate salt complex of the at least one pharmaceutical active ingredient for incorporating into said therapeutic solid dosage form.
Dependencies are inferred from the claim text.