US 8,012,498 B2 · Topical gel formulation comprising organophosphate insecticide and preparation thereof

Abstract

The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

Claims56

Dependent claims

A topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising:

a) about 0.1-10% by weight of malathion;
b) at least about 75% by weight of ethyl alcohol or isopropyl alcohol;
and c) at least one cellulosic polymer selected from the group consisting of hydroxyl ethyl cellulose, hydroxy propyl cellulose, hydroxy propyl methyl cellulose, methyl cellulose, carboxy methyl cellulose, sodium carboxy methyl cellulose, and ethyl cellulose, wherein the formulation is free of added water.

Dependencies are inferred from the claim text.

Facts

Application

11/179,719Filed 12 Jul 2005 · us provisional application

Priority

12 Jul 2004

Published

US 2006/0084632 A120 Apr 2006

Granted

6 Sep 2011

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A01N 57/14
Having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds: containing aromatic radicals
A01N 25/04
Containing liquids as carriers, diluents or solvents: dispersions, emulsions, suspoemulsions, suspension concentrates or gels
A01N 37/02
Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to…:…
A01N 53/00
Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic

Family

Application60/587,291Us provisional application · filed 12 Jul 2004

Application60/645,781Us provisional application · filed 21 Jan 2005

Application60/646,826Us provisional application · filed 25 Jan 2005

US 2006/0084632 A1Pre-grant publication · published 20 Apr 2006

US 8,012,498 B2This patent

From the US filing history. Foreign family members aren’t listed.

Topical gel formulation comprising organophosphate insecticide and preparation thereof

Life of this patent

Topical gel formulation comprising organophosphate insecticide and preparation thereof

Life of this patent

Abstract

Claims56