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US 8,012,488 B2Granted
Polyoxyalkylene derivative
AssigneeNof Corporation
InventorsKenji Sakanoue, Kenichiro Nakamoto, Yuji Yamamoto, Hiroki Yoshioka
Life of this patent
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Abstract
A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various physiologically active substances according to the object is provided.
Claims17
A polyoxyalkylene derivative represented by the following formula (1)
- wherein
- Z is a peptide residue consisting of 2 to 10 amino acid residues, wherein one or more amino acid residues have a side chain containing a functional group,
- OA is an oxyalkylene group having 2 to 4 carbon atoms,
- R is a hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms,
- X1 is a group containing a succinimide group, a maleimide group, an amino group, a carboxyl group, a carbonate group, an aldehyde group, a sulfonyl group, a thiol group, or a vinyl group,
- X2 is a group containing a succinimide group, a maleimide group, an amino group, a carboxyl group, a carbonate group, an aldehyde group, a sulfonyl group, a thiol group, a vinyl group, or a hydroxyl group,
- Y and W are each independently a divalent group containing a group selected from the group consisting of
- —S—S— and —O—, wherein at least one Y and/or W moiety differs from the remaining Y and W moieties,
- n is an integer of 5-1000, m is an integer of 5-800, j1 is an integer of 0-8, j2 is an integer of 0- 8, k is an integer of 0-8, wherein 1≦j1+j2≦12, 3≦k+j1+j2≦12, 30≦(n×k)+(m×j1)≦2000.
6 more elements
Dependencies are inferred from the claim text.