Drug conjugate composition
AssigneeImmunoGen, Inc.
InventorsGodfrey Amphlett, Wei Zhang, Michael Fleming
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Abstract
The invention provides a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human the reconstituted composition such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.
Claims13
A lyophilized composition comprising (i) a therapeutically effective amount of a conjugate comprising a humanized antibody that binds to an antigen on the surface of a cell wherein the antibody is chemically coupled to a maytansinoid that is N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine (DM1) or N2′-deacetyl-N2′-(4-mercapto-4-methyl-1-oxopentyl)-maytansine (DM4), (ii) about 0.1 mg to about 2 mg of sodium succinate per mg of the conjugate, (iii) about 0.5 mg to about 5 mg of sucrose per mg of the conjugate, and (iv) about 2 mg to about 20 mg of glycine per mg of the conjugate, wherein the composition has a pH of about 5-6 when reconstituted with water.
Dependencies are inferred from the claim text.