Humanized anti-TGF-beta antibodies

A humanized antibody that binds a TGF-beta1, TGF-beta2 or TGF-beta3 protein, the humanized antibody comprising:

• a variable heavy (VH) domain that comprises the non-human hypervariable region residues of SEQ ID NO:
• 21, SEQ ID NO:
• 22 and SEQ ID NO:
• 23 incorporated into a human VH domain, said variable domain further comprising a framework region (FR) comprising the framework residues of SEQ ID NO:6 and comprising one or more FR substitutions in SEQ ID NO:6 at a position selected from the group consisting of 48, 49, 68, and 72;
• and
• a variable light (VL) domain chain that comprises complementarity-determining-region (CDR) residues RASQSVLYSSNQKNYLA (SEQ ID NO:18) or RASQGISSYLA (SEQ ID NO:7);
• WASTRES (SEQ ID NO:19) or YASSLQS (SEQ ID NO:8);
• and HQYLSSDT (SEQ ID NO:20).