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US 8,012,466 B2Granted
Immunogenic compositions for activating γδ T cells
AssigneeUniversity of Iowa Research Foundation
InventorsCraig T. Morita, Bradley D. Jones
Life of this patent
Estimating the term…
Abstract
Disclosed are compositions, kits, and methods for activating, expanding, or stimulating γδ T cells that include recombinant attenuated microbes. The compositions may include pharmaceutical compositions that are used as γδ T cell stimulating immunogenic compositions.
Claims26
An immunogenic composition comprising:
- (a) an effective amount of a recombinant attenuated microbe for activating, expanding, or stimulating γδ T cells in a subject, wherein the microbe comprises a mutation in lytB and the microbe comprises one or more heterologous genes for production of mevalonate;
- and (b) an excipient.
A recombinant attenuated Salmonella spp. bacteria, wherein the bacteria comprises a mutation in lytB and the bacteria comprises one or more heterologous genes for production of mevalonate.
Dependencies are inferred from the claim text.