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AssigneeKyushu University, National University Corporation
InventorsKunio Ishikawa, Shigeki Matsuya, Masaharu Nakagawa, Kouichi Udou
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There is disclosed a bone substitute material for medical use which satisfies all the requirements of (1) no histotoxicity, (2) osteoconductivity, (3) bone replacement capability, and (4) mechanical strength necessary for a bone reconstruction operation. The bone substitute material for medical use is predominantly composed of carbonate apatite and produced through the formation of carbonate apatite by contacting a block of calcium compound with a phosphate-containing solution, wherein the calcium compound block contains substantially no powders, and at least one of said calcium compound block and said phosphate solution contains a carbonate group, without any sintering. The block of calcium compound is preferably one prepared using an artificially synthesized calcium compound, most preferably a foamed calcium compound.
A method of producing a bone substitute material in the form of a block predominantly composed of carbonate apatite for medical use, which comprises the step of forming carbonate apatite by contacting a porous block of calcium compound with a phosphate-containing solution, wherein said porous calcium compound block contains substantially no powders such that powders with a diameter of 20 micrometers or smaller are less than 1.0% by weight of said porous calcium compound block, wherein at least one of said porous calcium compound block and said phosphate solution contains a carbonate group, and wherein the method does not include any sintering step, and wherein the porous block of calcium compound is one prepared using an artificially synthesized calcium compound, the porous block having an average pore diameter in a range of 50-1000 μm.
A bone substitute material produced by a method comprising forming carbonate apatite by contacting a porous block of calcium compound with a phosphate-containing solution, wherein said porous calcium compound block contains substantially no powders such that powders with a diameter of 20 micrometers or smaller are less than 1.0% by weight, wherein at least one of said porous calcium compound block and said phosphate solution contains a carbonate group, and wherein the method does not include any sintering step, and wherein the bone substitute material is predominantly composed of carbonate apatite, and wherein the porous block of calcium compound is one prepared using an artificially synthesized calcium compound, the porous block having an average pore diameter in a range of 50-1000 μm.
A method of producing a bone substitute material predominantly composed of carbonate apatite, comprising:
Dependencies are inferred from the claim text.