US 8,012,118 B2 · Artificial kidney dialysis system

Abstract

The present disclosure relates to a wearable dialysis system and method for removing uremic waste metabolites and fluid from a patient suffering from renal disease. Uremic waste metabolites can be removed by a wearable peritoneal dialysis device that regenerates the peritoneal dialysis solution without removing positively charged, essential ions from the solution and, consequently, the patient. Fluids can be removed from the blood of the patient by an implantable fluid removing device. Fluids are delivered to the bladder and preferably removed from the body of the patient through urination. The wearable dialysis system may be operated continuously or semi-continuously and be comfortably adapted to the body of the patient while allowing the patient to perform normal activities.

Claims32

Dependent claims

A method for the removal of uremic waste metabolites and excess fluid from a patient using a wearable peritoneal dialysis device and an implanted fluid removing device comprising:

a) providing a volume of peritoneal dialysis solution;
b) pumping the peritoneal dialysis solution into the peritoneal cavity of the patient through an access port, allowing the patient's uremic waste metabolites to diffuse through the peritoneal membrane and thereby come into contact with and dissolve in the peritoneal dialysis solution;
c) pumping the peritoneal dialysis solution containing uremic waste metabolites out of the patient and into the device;
d) filtering particulates and debris from the peritoneal dialysis solution containing uremic waste metabolites;
e) regenerating the peritoneal dialysis solution containing uremic waste metabolites;
f) returning the regenerated peritoneal dialysis solution to the patient's peritoneal cavity;
and
g) removing excess fluid from the blood stream of said patient with the implanted fluid removing device that comprises a plurality of hollow fiber membranes, said implanted fluid removing device connected to the blood stream of said patient by vascular grafts,
thereby enabling the patient to maintain a relatively normal, active lifestyle.

6 more elements

A dialysis system for a patient comprising:

a) a wearable peritoneal dialysis device comprising:
i) a volume of peritoneal dialysis solution for infusion into and moving out of the patient's peritoneal cavity, allowing the patient's uremic waste metabolites to diffuse through the peritoneal membrane and thereby come into contact with and dissolve in the peritoneal dialysis solution, thereby removing from the patient uremic waste metabolites that have diffused into the peritoneal dialysis solution,
ii) a closed fluid system loop for circulating the peritoneal dialysis solution from the patient, throughout the wearable peritoneal dialysis device and back into the patient,
iii) at least one pump attached to the fluid system loop for infusing the peritoneal dialysis solution into the patient's peritoneal cavity and moving the peritoneal dialysis solution containing uremic waste metabolites out of the patient's peritoneal cavity and into the fluid system loop,
iv) a filter attached to the fluid system loop for removing particulates and debris from the peritoneal dialysis solution containing uremic waste metabolites, and
v) a urea removal device attached to the fluid system loop for regenerating the peritoneal dialysis solution;
and
b) an implanted fluid removing device that comprises a plurality of hollow fiber membranes, for removing excess fluid from the blood stream of said patient, said implanted fluid removing device connected to the blood stream of said patient by vascular grafts,
thereby enabling the patient to maintain a relatively normal, active lifestyle.

6 more elements

A method for the removal of uremic waste metabolites and excess fluid from a patient using a wearable peritoneal dialysis device and an implanted fluid removing device comprising:

a) providing a volume of peritoneal dialysis solution;
b) pumping the peritoneal dialysis solution into the peritoneal cavity of the patient through an access port, allowing the patient's uremic waste metabolites to diffuse through the peritoneal membrane and thereby come into contact with and dissolve in the peritoneal dialysis solution;
c) pumping the peritoneal dialysis solution containing uremic waste metabolites out of the patient and into the device;
d) filtering particulates and debris from the peritoneal dialysis solution containing uremic waste metabolites;
e) regenerating the peritoneal dialysis solution containing uremic waste metabolites;
f) returning the regenerated peritoneal dialysis solution to the patient's peritoneal cavity;
and
g) removing excess fluid from the blood stream of said patient with the implanted fluid removing device connected to the blood stream of said patient by vascular grafts, said fluid removing device comprising:
i) a first header defining a first flow path having a single inlet and multiple outlets and a means for uniformly distributing fluid flow from the single inlet to the multiple outlets;
ii) a second header defining a second flow path having multiple inlets and a single outlet;
iii) a filter in fluid communication with said first header and said second header;
iv) a first graft for connecting the vascular system of the patient to the single inlet;
v) a second graft for connecting the single outlet to the vascular system of the patient;
vi) a housing adapted to collect fluid that passes through the filter;
and
vii) a drain conduit connected to the housing.

13 more elements

A dialysis system for a patient comprising:

a) a wearable peritoneal dialysis device comprising:
i) a volume of peritoneal dialysis solution for infusion into and moving out of the patient's peritoneal cavity, allowing the patient's uremic waste metabolites to diffuse through the peritoneal membrane and thereby come into contact with and dissolve in the peritoneal dialysis solution, thereby removing from the patient uremic waste metabolites that have diffused into the peritoneal dialysis solution,
ii) a closed fluid system loop for circulating the peritoneal dialysis solution from the patient, throughout the wearable peritoneal dialysis device and back into the patient,
iii) at least one pump attached to the fluid system loop for infusing the peritoneal dialysis solution into the patient's peritoneal cavity and moving the peritoneal dialysis solution containing uremic waste metabolites out of the patient's peritoneal cavity and into the fluid system loop,
iv) a filter attached to the fluid system loop for removing particulates and debris from the peritoneal dialysis solution containing uremic waste metabolites, and
v) a urea removal device attached to the fluid system loop for regenerating the peritoneal dialysis solution;
and
b) an implanted fluid removing device for removing excess fluid from the blood stream of said patient, said implanted fluid removing device connected to the blood stream of said patient by vascular grafts, said fluid removing device comprising:
i) a first header defining a first flow path having a single inlet and multiple outlets and a means for uniformly distributing fluid flow from the single inlet to the multiple outlets;
ii) a second header defining a second flow path having multiple inlets and a single outlet;
iii) a filter in fluid communication with said first header and said second header;
iv) a first graft for connecting the vascular system of the patient to the single inlet;
v) a second graft for connecting the single outlet to the vascular system of the patient;
vi) a housing adapted to collect fluid that passes through the filter;
and
vii) a drain conduit connected to the housing.

13 more elements

Dependencies are inferred from the claim text.

Artificial kidney dialysis system

Life of this patent

Artificial kidney dialysis system

Life of this patent

Abstract

Claims32