Method and system for high throughput mass analysis
AssigneesMax-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V., Georg-August-Universitat Gottingen
InventorsBernd Abel, Jürgen Troe, Ales Charvat
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Abstract
The invention relates to a test method, especially for mass spectroscopy of biomolecules, including the following steps: one or several samples (2-4) that are to be analyzed are introduced into a carrier liquid of a micro liquid jet (1) in rapid succession; at least some of the samples (2-4) are desorbed from the micro liquid jet (1); and the sample (2-4) that is desorbed from the micro liquid jet (1) is analyzed. According to the invention, the sample (2-4) is spatially delimited in the spraying direction in the micro liquid jet (1) while extending only along a subarea of the micro liquid jet (1) in the spraying direction.
Claims25
A test method comprising the following steps:
- a) introduction of a sample to be analyzed into a carrier liquid,
- b) generation of a micro liquid jet from the carrier liquid with the sample contained therein,
- c) desorption of at least one part of the sample from the micro liquid jet,
- d) analysis of the sample desorbed from the micro liquid jet, wherein the sample in the micro liquid jet is spatially delimited in a jet direction and extends in the jet direction only along a portion of the micro liquid jet.
A test system comprising:
- a) a micronozzle for generating a micro liquid jet, the micro liquid jet containing a carrier liquid and at least one sample to be analyzed,
- b) a desorption apparatus for the desorption of at least a part of the sample from the micro liquid jet,
- c) an analyzing apparatus for analyzing the desorbed sample, and
- d) an injection apparatus that injects the sample into the carrier liquid of the micro liquid jet in a locally delimited manner so that the sample in the micro liquid jet extends in a jet direction only along a portion of the micro liquid jet.
A micro liquid jet containing a carrier liquid and at least one sample introduced into the carrier liquid, wherein the sample in the micro liquid jet is spatially delimited in the jet direction and extends in the jet direction only over a portion of the micro liquid jet and wherein individual samples form segments in the micro liquid jet, that otherwise consists of the carrier liquid.
Dependencies are inferred from the claim text.