Back to results
US 8,008,620 B2Granted
Substrate for mass spectrometry and mass spectrometry method
AssigneeFUJIFILM Corporation
InventorsMorihito Ikeda, Naoki Murakami
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeFUJIFILM Corporation
InventorsMorihito Ikeda, Naoki Murakami
Estimating the term…
A substrate for mass spectrometry includes a first reflective member that is semi-transmissive/semi-reflective, a transparent member, and a second reflective member that is reflective, sequentially provided to form an optical resonator. The optical resonator includes, on a surface of the first reflective member, a sample separation portion at which surface interaction occurs with a plurality of analytes contained in a sample liquid. The analytes are separated on the sample separation portion to perform mass spectrometry on each of the analytes. A sample in contact with the surface of the first reflective member is irradiated with laser beam L to generate resonance in the optical resonator, and an electric field on the surface of the first reflective member is enhanced by the resonance. The enhanced electric field is utilized to ionize analytes S in the sample and to desorb the analytes S from the surface.
A substrate for mass spectrometry used in a mass spectrometry method in which a substance fixed on a surface of the substrate is irradiated with a laser beam to be ionized and to be desorbed from the surface, and the ionized substance is captured to perform mass spectrometry, the substrate comprising:
Amass spectrometry method, wherein a substrate for mass spectrometry including a first reflective member that is semi-transmissive and semi-reflective, a transparent member, and a second reflective member that is reflective is used, and wherein the first reflective member, the transparent member and the second reflective member are sequentially provided to form an optical resonator that generates resonance in the transparent member by irradiation of a surface of the first reflective member with a laser beam, and wherein the optical resonator includes, on the surface of the first reflective member, a sample separation portion at which surface interaction occurs with a plurality of analytes contained in a sample liquid, the method comprising the steps of:
A substrate for mass spectrometry used in a mass spectrometry method in which a substance fixed on a surface of the substrate is irradiated with a laser beam to be ionized and to be desorbed from the surface, and the ionized substance is captured to perform mass spectrometry, wherein the surface of the substrate is a rough metal surface that excites localized plasmons by irradiation with a laser beam and that generates a hot spot, and wherein the rough metal surface has a sample separation portion at which surface interaction occurs with a plurality of analytes contained in a sample liquid.
Amass spectrometry method, wherein a substrate for mass spectrometry having a rough metal surface that excites localized plasmons by irradiation with a laser beam and that generates a hot spot is used, and wherein the rough metal surface has a sample separation portion at which surface interaction occurs with a plurality of analytes contained in a sample liquid, the method comprising the steps of:
Dependencies are inferred from the claim text.