Generation of transgenic human soluble amyloid precursor protein alpha expressing mice
AssigneeUniversity of South Florida
InventorsJun Tan, William Nikolic, Huyan Hou
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Abstract
The present invention relates to a novel animal model for neurological degenerative diseases, especially autism, relating to overexpression of human secreted APP-alpha. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method for producing the double transgenic animals, to cells and cell lines derived from these animals. Moreover, a method for the evaluation of the in vivo effects of a test compound on secreted APP-alpha expression and autism pathology in these animals is provided.
Claims2
A transgenic mouse or progeny thereof whose genome comprises a transgene, said transgene having a nucleic acid encoding a secreted soluble human amyloid precursor protein alpha (sAPP-alpha) operably linked to a promoter capable of driving expression of a gene in the brain, wherein said transgenic mouse overexpresses sAPP-alpha in its brain, wherein said transgenic mouse is homozygous for said transgene, and wherein said transgenic mouse develops at least one symptom associated with autism.
Dependencies are inferred from the claim text.