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US 8,008,531 B2Granted
Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
AssigneeThe Florida State University Research Foundation, Inc.
InventorGregory Dudley
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Abstract
A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
Claims12
A process for benzylating an alcohol, the process comprising:
- mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point;
- adding an acid scavenger to the mixture;
- combining the alcohol to be benzylated with the mixture;
- reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol;
- and
- separating the benzylated alcohol from the mixture.
3 more elements
Dependencies are inferred from the claim text.