Receptor function regulating agent
AssigneeTakeda Pharmaceutical Company Limited
InventorsKohji Fukatsu, Ryo Fujii, Makoto Kobayashi, Jinichi Yonemori, Toshio Tanaka
Life of this patent
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Abstract
An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.
Claims5
A compound represented by the formula:
- wherein Ra is a fluorine atom, or a C1-6 alkoxy group
- Rb is a hydrogen atom, or a fluorine atom;
- Rc is a hydrogen atom, or a C1-6 alkyl group;
- Xa is an oxygen atom;
- ring C is a benzene ring optionally having, in addition to Rd and Re, further substituent(s) selected from the group consisting of (i) a C1-6 alkyl group, (ii) a hydroxy group, (iii) a C1-6 alkoxy group having substituent(s) selected from the group consisting of hydroxy, amino, C1-6 alkoxy-carbonyl-amino, carboxy, C1-6 alkoxy-carbonyl, carbamoyl, mono-C1-6 alkyl-carbamoyl, di-C1-6 alkyl-carbamoyl, and tri-C1-6 alkylsilyloxy, (iv) a C6-14 aryloxy group, and (v) a C7-16 aralkyloxy group;
- and
- one of Rd and Re is a hydrogen atom,
- (1) when Rd is a hydrogen atom,
- then Re should be (i) a hydroxy group, (ii) a C1-6 alkoxy group having substituent(s) selected from the group consisting of C1-6 alkoxy, carboxy, C1-6 alkoxy-carbonyl, C1-6 alkyl-carbonyl, carbamoyl, mono-C1-6 alkyl-carbamoyl, and di-C1-6 alkyl-carbamoyl, (iii) a C2-6 alkynyloxy group, (iv) a C3-7 cycloalkyloxy group, (v) a C6-14 aryloxy group optionally having substituent(s) selected from the group consisting of a halogen atom, C1-6 alkyl, C1-6 alkoxy, and C1-6 alkyl-carbonyl, or (vi) a 5- to 10-membered heterocyclyl-oxy group containing, in addition to carbon atom(s), 1 to 4 heteroatoms of one or two kinds selected from a nitrogen atom, a sulfur atom and an oxygen atom;
- (2) when Re is a hydrogen atom,
- then Rd should be, (i) a C6-14 aryl group, (ii) a C3-7 cycloalkyloxy group, (iii) a C6-14 aryloxy group optionally having substituent(s) selected from the group consisting of a halogen atom and optionally halogenated C1-6 alkyl, (iv) a C7-16 aralkyloxy group, or (v) a 5- to 7-membered heterocyclic group containing, in addition to carbon atom(s), 1 to 4 heteroatoms of one or two kinds selected from a nitrogen atom, a sulfur atom, and an oxygen atom,
- or a salt thereof.
3,5-Difluoro-4-[(3-phenoxyphenyl)methoxy]benzenepropanoic acid, or 3-fluoro-4-[(3-phenoxyphenyl)methoxy]benzenepropanoic acid, or a salt thereof.
3-(4-{[3-(4-Chlorophenoxy)benzyl]oxy}-3,5-difluorophenyl)propanoic acid, 3-(3,5-difluoro-4-{[3-(4-fluorophenoxy)benzyl]oxy}phenyl)propanoic acid, 3-(3,5-difluoro-4-{[3-(4-methylphenoxy)benzyl]oxy}phenyl)propanoic acid, 3-(3-fluoro-4-{[3-(2-fluorophenoxy)benzyl]oxy}phenyl)propanoic acid, 3-(3-fluoro-4-{[3(3-fluorophenoxy)benzyl]-oxy}phenyl)propanoic acid, 3-(3-fluoro-4-{[3-(4-fluorophenoxy)benzyl]oxy}phenyl)propanoic acid, 3-(3-fluoro-4-{[3-(4-chlorophenoxy)benzyl]oxy}phenyl)propanoic acid, 3-(3-fluoro-4-{[3-(4-methylphenoxy)benzyl]oxy}phenyl)propanoic acid, 3-{3-methyl-4-[(3-phenoxybenzyl)oxy]phenyl}propanoic acid, or 3-(4-{[3-(4-fluorophenoxy)benzyl]oxy}-3-methylphenyl)propanoic acid, or a salt thereof.
Dependencies are inferred from the claim text.