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US 8,008,522 B2Granted
Phosphonate fluorescent dyes and conjugates
AssigneeElitech Holding B.V.
InventorsEugeny Lukhtanov, Alexei Vorobiev
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Abstract
Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.
Claims4
A compound having the formula:
- wherein
- L is a member selected from the group consisting of a (C1-C20)alkylene and (C1-C20) heteroalkylene linking group;
- X is a member selected from the group consisting of a functional group and a protected functional group wherein said functional group is hydroxy, diol, carboxy, formyl, carbonyl, thio, aminooxy, azido, carbazoyl, hydrazine, or amino having the formula NRARB;
- R is —(CH2)n—NRARB, wherein n is 3, 4, or 5;
- wherein
- RA is H or (C1-C8)alkyl and RB is selected from the group consisting of —C(O)CF3, —C(O)OtBu, FMOC, monomethoxytrityl and —C(O)O-benzyl.
3 more elements
Dependencies are inferred from the claim text.