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US 8,008,513 B2Granted
4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
AssigneeJanssen Pharmaceutica NV
InventorsGee-Hong Kuo, Rui Zhang, Aihua Wang, Alan R. DeAngelis
Life of this patent
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Abstract
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
Claims22
A compound of Formula (II):
- wherein
- X is selected from a covalent bond, S, and O;
- Y is S or O;
- R1 and R2 are independently selected from H, C1-3 alkyl, C1-3 alkoxy, halo, and NRaRb wherein Ra and Rb are independently H or C1-3 alkyl;
- R3 and R4 are independently selected from H, halo, cyano, C1-5 alkyl, hydroxy, C2-4 acyl, C1-4 alkoxy, and NRcRd wherein Rc and Rd are independently H or C1-3 alkyl, provided that R3 and R4 are not both H;
- R5 and R6 are independently selected from halo, phenyl, C1-9 alkyl, C1-8 alkoxy, C2-9 alkenyl, C2-9 alkenyloxy, C3-7 cycloalkyl, C3-7 cycloalkoxy, C3-7cycloalkyl-C1-7alkyl, C3-7cycloalkyl-C1-7alkoxy, C3-7cycloalkyloxy-C1-8alkyl, and C3-7cycloalkyloxy-C1-7alkoxy, or
- R5 and R6 together form C1-9 alkylidenyl or C3-9 alkenylidenyl;
- or R5,
- R6 and the carbon atom to which they are attached together form C3-7cycloalkyl or 5- or 6-membered heterocyclyl;
- n is 0, 1 or 2;
- and
- m is 0, 1 or 2;
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.