Metalloprotein inhibitors
AssigneeThe Regents of the University of California
InventorsDavid T. Puerta, Seth M. Cohen, Jana A. Lewis
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Abstract
The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
Claims6
A method of inhibiting metalloprotein activity in a mammal or of treating a mammal in need of therapy for a pathology, condition, or symptom associated with metalloprotein activity, which comprises administering to the mammal an effective amount of a compound of formula
- wherein X is O, and wherein R1, R2, and R3 is each hydrogen, and wherein R4 is biphenylcarbamyl- (C1)alkyl, biphenyl(C1-C6)alkylcarbamyl, (C1)alkyl, or phenoxyphenylcarbamyl (C1)alkyl,
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.