Indazole or 4,5,6,7-tetrahydro-indazole derivatives

Compounds of the formula

• wherein
• R1 is a ring selected from the group consisting of phenyl, naphthyl and heteroaryl, said ring being unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy and cyano;
• R2, R3, R4 and R5 independently from each other are selected from the group consisting of hydrogen, halogen or lower alkyl;
• R2′ and R3′ together as well as R4′ and R5′ together are replaced by a double bond, or R2′, R3′, R4′ and R5′ are hydrogen;
• R6 is selected from the group consisting of hydrogen, methyl, ethyl, hydroxy, methoxy, fluoro, fluoromethyl, difluoromethyl and trifluoromethyl;
• R7 is selected from the group consisting of lower alkyl, cycloalkyl, lower cycloalkylalkyl, lower alkoxyalkyl,
• unsubstituted phenyl or phenyl substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy and cyano,
• lower phenylalkyl, wherein the phenyl is unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy and cyano,
• unsubstituted heteroaryl or heteroaryl substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy and cyano, and
• heterocyclyl;
• and
• R8 is selected from the group consisting of —C(O)—NH—R9,
• —CR11R12—OR10, —O—(CR11R12)n—R10;
• —CR11R12—SR10, —CR11R12—SO2—R10,
• —CR11R12—NR13—R10;
• —CH═CH—R10 and —(CH2)p—R10,
• wherein
• n is 0 or 1, p is 2,
• R9 is selected from the group consisting of
• lower alkyl, cycloalkyl, lower cycloalkylalkyl,
• cycloalkyl substituted with 1 to 3 substituents independently selected from the group consisting of hydroxy, carboxyl, tetrazolyl, lower carboxylalkyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkoxy and lower alkoxycarbonylalkoxy, heterocyclyl,
• unsubstituted phenyl and phenyl substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy, carboxyl, tetrazolyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkyl, lower carboxylalkoxy, lower alkoxycarbonylalkoxy, cyano and cycloalkyloxy, wherein the cycloalkyl group is substituted by carboxyl, lower alkoxycarbonyl or tetrazolyl;
• R10 is selected from the group consisting of
• lower alkyl, cycloalkyl, lower cycloalkylalkyl,
• cycloalkyl substituted with 1 to 3 substituents independently selected from the group consisting of hydroxy, carboxyl, tetrazolyl, lower carboxylalkyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkoxy and lower alkoxycarbonylalkoxy, heterocyclyl,
• unsubstituted pyridyl and pyridyl substituted by carboxyl, lower alkoxycarbonyl or tetrazolyl,
• unsubstituted phenyl and phenyl substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy, carboxyl, tetrazolyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkyl, lower carboxylalkoxy, lower alkoxycarbonylalkoxy, cyano and cycloalkyloxy wherein the cycloalkyl group is substituted by carboxyl, lower alkoxycarbonyl or tetrazolyl, and
• lower phenylalkyl, wherein the phenyl is unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy, carboxyl, tetrazolyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkyl, lower carboxylalkoxy, lower alkoxycarbonylalkoxy, cyano and cycloalkyloxy wherein the cycloalkyl group is substituted by carboxyl, lower alkoxycarbonyl or tetrazolyl;
• R11 and R12 independently are selected from the group consisting of hydrogen, lower alkyl and lower halogenalkyl,
• or R11 and R12 together with the carbon atom to which they are attached form a cycloalkyl or alkoxycycloalkyl ring;
• and
• R13 is selected from the group consisting of hydrogen, lower alkyl and lower halogenalkyl;
• or pharmaceutically acceptable salts thereof.