Back to results
US 8,008,502 B2Granted
Thiazoline acid derivatives
AssigneeUniversity of Florida Research Foundation, Inc.
InventorRaymond J. Bergeron
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are useful in diagnosing and treating pathological conditions associated with an excess of trivalent metals in humans and animals.
Claims18
A method of preparing a compound of the formula:
- wherein:
- Z is CH or N;
- R is H or acyl;
- R1, R2, R3 and R5 may be the same or different and represent H, alkyl or hydrocarbyl arylalkyl having up to 14 carbon atoms;
- R4 is H or alkyl having 1-4 carbon atoms, and salts thereof with a pharmaceutically acceptable acid, comprising reacting a first reagent of the formula:
- with a second reagent of the formula:
- or a salt thereof with a pharmaceutically acceptable acid.
4 more elements
Dependencies are inferred from the claim text.