Polymorphic forms of aripiprazole and method
AssigneeSandoz Ltd.
InventorsJosef Wieser, Hannes Lengauer, Doris Braun, Ulrich Griesser, Richard Tessadri
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Abstract
The present invention relates to novel polymorphic forms of aripiprazole and processes for producing them. It further relates to pharmaceutical compositions comprising the novel forms and to the use of the novel forms in the treatment of schizophrenia.
Claims13
Process for preparing form X of aripiprazole, comprising the steps of:
- a) dissolving aripiprazole in a suitable solvent by heating
- b) slowly cooling the solution to room temperature or below to effect crystallization
- c) optionally isolating crystalline form X of aripiprazole.
Process for preparing form X of aripiprazole wherein a mixture of aripiprazole in a suitable solvent is seeded with crystals of form X aripiprazole and the mixture is stirred at a suitable temperature in order to effect transformation of the form of aripiprazole in the mixture into form X aripiprazole.
Process for preparing form X of aripiprazole, comprising the steps of:
- a) dissolving aripiprazole in a solvent medium which excludes pure water, ethanol, and methanol by heating the aripiprazole in the solvent medium to form a solution thereof
- b) cooling the solution to room temperature or below to effect crystallization
- c) isolating crystalline form X of aripiprazole from the solution.
Process for preparing form X of aripiprazole, comprising the steps of:
- a) dissolving aripiprazole in a solvent medium comprising a solvent selected from the group consisting of acetone, tetrahydrofuran and 2-propanol by heating the aripiprazole in the solvent medium to form a solution thereof
- b) cooling the solution to room temperature or below to cause formation of crystals therein containing substantially pure crystalline form X of aripiprazole, and
- c) isolating crystalline form X of aripiprazole from the solution.
Dependencies are inferred from the claim text.