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US 8,008,480 B2Granted
Process for the purification of meloxicam
AssigneeNorbrook Laboratories Limited
InventorsLiam McElroy, Lillian Cromie, Mark Garret
Life of this patent
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Abstract
A process for purifying meloxicam form I from a crude meloxicam, which comprises: i. contacting the crude meloxicam with an amine in a non-aqueous solvent to form a meloxicam salt; ii. isolating the meloxicam salt; iii. dissolving the meloxicam salt in an aqueous solvent to form a salt solution; and iv. adding an acid to the salt solution to precipitate free meloxicam.
Claims15
A process for purifying meloxicam form I from a crude meloxicam, which comprises:
- i. contacting the crude meloxicam with an amine in a non-aqueous solvent to form a meloxicam salt;
- ii. precipitating the meloxicam salt;
- iii. isolating the meloxicam salt by filtration;
- iv. dissolving the meloxicam salt in an aqueous solvent to form a salt solution;
- and
- v. adding an acid to the salt solution to precipitate free meloxicam.
3 more elements
Dependencies are inferred from the claim text.